Do Patients with Chronic Diseases Have a Higher Risk of Developing Cancer?
People with chronic conditions, such as diabetes or chronic obstructive pulmonary disease (COPD), spend enough time managing their symptoms and staying healthy. Should they worry that they might be at...
View ArticleA Tale of Two Genomes: Mitochondrial Genomics and Cancer Risk
Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis, and as a result, mitochondrial variations that affect these functions may contribute to the...
View ArticleHow Can Future Research Efforts Address Combined Environmental Exposures?
We are exposed to numerous chemical contaminants and non-chemical stressors (e.g., diet, infectious agents, and stress) on a daily basis. A “single-environmental-exposure” approach, which focuses...
View ArticleShifting the Cancer Research Paradigm: Early-Life Exposures and Cancer Risk...
Most cancer research in human populations has focused on a range of exposures in the middle to last 25th percentile of the lifespan. While this narrow age range yields the highest number of cancer...
View ArticleThe Continued Importance of Research in Gene-Environment Interactions in 21st...
Cancer risk is determined by a complex interplay of genetic and environmental factors. To understand this interplay, epidemiologic studies need to consider the effects of gene-environment (GxE)...
View ArticleIntegrating Host and Tumor Genome Data Holds Promise for Understanding Cancer...
Cancer is a disease of two genomes—the host, or germline genome, and the tumor, or somatic genome—and extensive data have been generated from both genomes. Most studies of cancer risk focus on the...
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